Moderna study suggests half doses offer strong immune response, but experts caution against changing approach – CBC

‘Significant’ immune response from both full and half doses, company’s team says

 Feb 17, 2021

There’s now early evidence showing Moderna’s coronavirus vaccine may elicit a strong immune response even through half doses, prompting hope that further research could back up the results and eventually allow countries like Canada to stretch out vaccine supplies.

The company’s peer-reviewed findings, based on a Phase 2 trial, were published online by the journal Vaccine last week.

The study looked at the mRNA vaccine’s “immunogenicity” — its ability to provoke an immune response — through both anti-virus, spike-binding antibody levels and neutralizing antibodies, which help to block reinfection.

Researchers determined within a two-dose regimen that both the current amount of vaccine dose and half that amount being given each time were capable of “significant” immune responses.

Read more: https://www.cbc.ca/news/health/moderna-half-doses-1.5915983

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