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First Nations Adults with Diabetes Have More than Double the Risk of End-Stage Kidney Disease

December 2, 2013 – In a new study published in the Canadian Medical Association Journal (CMAJ), the risk of end-stage renal disease was found to be 2.66 times higher for First Nations than non–First Nations adults with diabetes. Over 82% of First Nations people had diabetes before age 60, whereas most non–First Nations (56%) were over age 60.

Type 2 diabetes can result in end-stage renal disease after years of slow decline in kidney function, and among First Nations adults, it is increasingly occurring at a younger age. The authors recommend focusing on prevention strategies to reduce the number of new cases of diabetes and help delay the onset of end-stage kidney disease.

In a related paper in CMAJ, Alberta researchers found that rates of kidney disease are two to three times higher in First Nations people than in non–First Nations people. However, the association of albuminuria — the secretion of the protein albumin in urine, which indicates kidney problems — was similar in both First Nations and non–First Nations people. The Kidney Foundation is proud to support study coauthors Dr. Brenda Hemmelgarn through the Roy and Vi Baay Chair in kidney research, Dr. Susan Samuels through the KRESCENT Program and Drs. Manns and Tonelli through other research awards.

For more information:

“Differential mortality and the excess burden of end-stage renal disease among First Nations people with diabetes mellitus: a competing-risks analysis”

“Association between First Nations ethnicity and progression to kidney failure by presence and severity of albuminuria”